Association between cytotoxic T lymphocyte-associated antigen-4 gene polymorphism and Graves ophthalmopathy in Qinghai Han population
10.3760/cma.j.issn.2095-4255.2015.03.006
- VernacularTitle:细胞毒性T淋巴细胞相关抗原4基因多态性与青海省汉族人群Graves眼病相关性研究
- Author:
Shuqiong WANG
;
Yongli YAO
;
Wei LUO
;
Peiyun FAN
- Publication Type:Journal Article
- Keywords:
Cytotoxic T lymphocyte-associated antigen-4;
Polymorphism,single nucleotide;
Graves ophthalmopathy;
Han nationality
- From:
Chinese Journal of Endemiology
2015;34(3):175-177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between gene polymorphism of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and Graves ophthalmopathy (GO) in Qinghai Han population.Methods Ninety cases of Graves disease were selected from June 2011 to February 2014 in The People's Hospital of Qinghai Province,and the 90 patients were divided into two subgroups according to GO (49 cases) and GD without GO(41 cases).Then the genotype and allele of CTLA-4 exon 1 (+ 49A/G) were detected in surum by the method of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).Results The distribution of CTLA-4 exon 1 (+ 49 A/G) genotype frequencies (AA,AG,GG) was not different between GO and GD without GO subgroups [4.1％ (2/49) to 7.3％ (3/41),44.9％ (22/49) to 61.0％ (25/41),51.0％ (25/49) to 31.7％ (13/41),Fisher exact probability,P =0.180 ＞ 0.05]; the distribution of CTLA-4 exon 1 (+ 49A/G) allele frequencies (A,G) was not different between GO and GD without GO subgroups [26.5％ (26/98) to 37.8％ (31/82),73.5％ (72/98) to 62.2％ (51/ 82),x2 =2.622,P＞ 0.05].Conclusion CTLA-4 gene exon 1 (+ 49A/G) may not be a candidate susceptibility gene for Qinghai Han GO.
