Clinical Eeffects of Ferrocholinate in the Iron Deficiency Anemia of Children.
- Author:
Dong Hwan LEE
1
;
Jong Gu YOON
;
Kwang Wook KO
Author Information
1. Department of Pediatrics, College of Medicine, Seoul National University
- Publication Type:Original Article ; Clinical Trial
- MeSH:
Anemia, Hypochromic;
Anemia, Iron-Deficiency*;
Child*;
Choline;
Citric Acid;
Diarrhea;
Gastrointestinal Tract;
Heart Defects, Congenital;
Humans;
Iron*;
Nausea
- From:Journal of the Korean Pediatric Society
1978;21(9):568-572
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ferrocholinate, choline citrate iron salt is a new chelate iron which is synthesized by reacting ferric hydroxide with choline dihydrogen citrate. Ferrocholinate is used in the prevention and treatment of microcytic, hypochromic anemias due to iron deficiency. Ferrocholinate does not release high concentrations of free ionic iron in the gastrointestinal tract and clinical reports, although limited, seem to indicate that this drug is better tolerarated than is ferrous sulfate or ferrous gluconate. Ferrocholinate : syrup was administered to 19 patients of iron deficiency anemia. Ferrocholinate was administered orally. Therapeutic dosage was 1.2cc/kg (elementary iron 6mg/kg) divided three times daily. The results were obtained as follows. (Table 1) 1) In this clinical trials, the over-all effective rate was 84.2% 2) There was no effect on 3 cases who have combined with severe infection and congenital heart disease. 3) Of the 19 patients, 2 patients complained transient nausea and 1 patient mild diarrhea. These symptoms, however, disappeared along with continued therapy.
