Apnea of prematurity and intermittent hypoxic episodes
10.3760/cma.j.issn.1673-4912.2014.10.002
- VernacularTitle:早产儿呼吸暂停与间歇性缺氧
- Author:
Jian MAO
- Publication Type:Journal Article
- Keywords:
Apnea;
Intermittent hypoxic episode;
Preterm infant
- From:
Chinese Pediatric Emergency Medicine
2014;21(10):617-621
- CountryChina
- Language:Chinese
-
Abstract:
Current definition of apnea of prematurity (AOP) with the time of breathing cease equal or more than 20 seconds,or less than 20 seconds accompanying with bradycardia and(or) cyanosis was absence of strong clinical evidence and arbitrary.We have no consensus on the treatment of AOP,but severe AOP will lead to the intermittent hypoxic episodes(IHE) and severe fluctuation of oxygen saturation associated with severe retinopathy of prematurity and bad neurodevelopmental outcome.IHE occurred not only due to AOP,but also in the processes of continuous positive airway pressure and invasive ventilation.Decreasing the IHE is one of key problems of preterm respiratory support.Optimal target oxygen saturation should be regulated dynamically,the target oxygen saturation of 90％ ～ 95％ lowers IHE and mortality,but likely increases retinopathy of prematurity.Caffeine,the first choice of AOP,may be no of effect in the mixed or obstructive AOP which may need more respiratory support to reduce the lung volume loss and airway resistance.
