Effectiveness of using gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU: a systematic review
10.3760/cma.j.issn.1672-7088.2015.07.016
- VernacularTitle:重症监护机械通气患者应用氯己定含漱液效果的Meta分析
- Author:
Wenxia SUN
;
Yan QI
- Publication Type:Journal Article
- Keywords:
Chlorhexidine;
Nursing care;
Respiration,artificial;
Meta-analysis
- From:
Chinese Journal of Practical Nursing
2015;31(7):515-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the effectiveness of using gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU.Methods The randomized controlled trials (RCTs) on the application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU were collected through the databases such as the China National Knowledge Infrastructure (CNKI),China Scientific Journal Database by VIP (VIP) and Wanfang Database.The quality of studies was critically appraised and data were extracted by two reviewers independently.Meta-analysis was conducted for the included studies.Results Eleven RCTs involving 1 337 patients were included.Meta-analysis showed that the application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU could reduce ventilator-associated pneumonia (VAP) incidence rate[RR=0.54,95％CI(0.44-0.65),P ＜ 0.01],shorten the duration of mechanical ventilation [mean differences(MD)=-2.38,95％CI(-2.69--2.07),P ＜ 0.01] and length of ICU [MD=-3.66,95％CI (-5.45--1.87),P ＜ 0.01],but the mortality rate was not statistically significant [RR=0.37,95％CI (0.11-1.26),P ＞ 0.05].Conclusions The application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU is safe and effective.
