A new sight into mechanism of hypertriglyceridemia induced by hypothyroidism
10.3760/cma.j.issn.1000-6699.2014.06.009
- VernacularTitle:甲状腺功能减退导致高甘油三酯血症的分子机制的新认识
- Author:
Quanxi ZHENG
;
Kun WANG
;
Chao LIU
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Hypertriglyceridemia;
Apolipoprotein B48
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(10):856-858
- CountryChina
- Language:Chinese
-
Abstract:
Hypertriglyceridemia is one of the clinical manifestations of hypothyroidism.Besides regulating thyroid hormone axis,thyroid stimulating hormone (TSH) also has the effect on up-regulated expression of inflammatory cytokines.Synthesis of inflammatory factors can promote the expression of apolipoprotein B48 (ApoB48) in intestinal mucosal epithelial cells,suggesting that TSH may up-regulate the expression of ApoB48 by inducing inflammation; while theoratically,low-level of thyroid hormones can inhibit the synthesis of ApoB48.At the same time,since ApoB48 is the important cause of hypertriglyceridemia,there is a contradiction that it is difficult to explain the clinical phenomenon of hypertriglyceridemia induced by hypothyroidism.Therefore,hypothyroidism may affect the expression of ApoB48 by high level of TSH and low level of thyroid hormones,leading to hypertriglyceridemia.
