Improving angiogenesis in the myocardial tissue of diabetic cardiomyopathy by insulin treatment in rats
10.3760/cma.j.issn.1000-6699.2014.10.007
- VernacularTitle:胰岛素提高糖尿病心肌病大鼠心肌组织的血管生成
- Author:
Liquan CHEN
;
Chun GUI
;
Linlin CHEN
;
Xiaomin WEI
;
Zhongli TANG
;
Bing QI
- Publication Type:Journal Article
- Keywords:
Angiogenesis;
Insulin;
Diabetic cardiomyopathy;
Stable-isotope labeled microspheres;
Blood flow of myocardium
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(10):849-852
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic SD rats were established by injection of streptozotocin,and were divided into normal blood sugar control group(NC),diabetic control group(DM),and the insulin treatment group(IDM).12 weeks later,the maximum rates of increasing and decreasing pressure in left ventricle were both decreased in DM group(P＜ 0.05),and those in IDM group were higher than those in DM group(P＜0.05).Regional myocardial blood flow in DM group was lower than that in NC group [(3.39 ± 0.48 vs 3.90 ± 0.45) ml · g-1 · min-1,P＜ 0.05],and that in IDM group was higher than that in DM group [(4.46 ± 0.52 vs 3.39 ± 0.48) ml · g-1 · min-1,P＜0.05].The capillary density ratio in DM group was lower than that of NC group [0.429 ± 0.091 vs 0.545 ± 0.082,P＜0.05],but that in IDM group was higher than DM group [0.494 ± 0.076 vs 0.429 ± 0.091,P＜0.05].VEGF and Ang-1 expression in DM group were the highest in 3 groups (P＜0.05).Insulin therapy may improve the angiogenesis and myocardial blood flow in diabetic rats with cardiomyopathy.
