Effect of gabapentin for treatment of neuropathic pain induced by bilateral sciatic nerve chronic constriction injury in rats
10.3760/cma.j.issn.0254-1416.2014.10.016
- VernacularTitle:加巴喷丁治疗双侧坐骨神经结扎诱发大鼠神经病理性痛的效应
- Author:
Si CHEN
;
Le SHEN
;
Hao LI
;
Ailun LUO
;
Xuerong YU
;
Yuguang HUANG
- Publication Type:Journal Article
- Keywords:
Cyclohexanecarboxylic acids;
Neuralgia
- From:
Chinese Journal of Anesthesiology
2014;34(10):1215-1219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of gabapentin for treatment of neuropathic pain induced by bilateral sciatic nerve chronic constriction injury (bCCI) of rats.Methods Forty-eight female SPF Sprague-Dawley rats,weighing 180-200 g,aged 7-9 weeks,were randomly divided into 4 groups (n =12 each) using a random number table:control group (C group),sham operation group (S group),bCCI group,and bCCI + gabapentin group (G group).Gabapentin 100 mg/kg was intraperitoneally injected once at 15 min before operation and twice a day during 7-13 days after operation for 7 consecutive days.The bilateral mechanical paw withdrawal threshold (MWT),thermal paw withdrawal latency (TWL) and number of cold-stimulated paw withdrawal were measured before operation (baseline) and at 1,3,6,8,10,14 days after operation.Results Compared with C group,the bilateral MWT was significantly decreased,and the bilateral TWL was shortened in bCCI and G groups,and no significant change was found in MWT and TWL in S group.Compared with bCCI group,the bilateral MWT was significantly increased,the bilateral TWL was prolonged,and no significant change was found in the number of cold-stimulated paw withdrawal in G group.Conclusion Gabapentin can relieve thermal and mechanical hyperalgesia induced by bCCI,however,it exerts no effect on cold allodynia in rats.
