The change of local vaginal microenvironment in atrophic vaginitis after estrogen therapy

VernacularTitle:萎缩性阴道炎患者雌激素治疗后阴道局部环境的变化
Author: Xuejing JIN ; Youta CHEN ; Pingsheng CAI ; Chun YAN
Publication Type:Journal Article
Keywords: Vaginitis; Estrogens; Interleukin-6; Interferon-γ
From: Chinese Journal of Geriatrics 2014;33(10):1107-1108
CountryChina
Language:Chinese
Abstract: Objective To investigate the change of local vaginal microenvironment in atrophic vaginitis after estrogen therapy.Methods A prospective study was conducted in 128 patients with atrophic vaginitis.The patients were treated with estriol cream by vaginal administration,and the efficacy was observed after treatment.Results The PH value was decreased and the detection rate of lactobacilli was significantly increased after estrogen therapy(P＜0.01).Average vaginal health score was also increased (P＜0.01).Interleukin-6 (IL 6) level in vaginal secretion was decreased after the treatment (P＜0.01).Interferon-γ (INF-γ) level was increased obviously after treatment,while there was no significant difference between the two groups(P＞0.05).Conclusions Estrogen can significantly improve the local vaginal microenvironment in atrophic vaginitis.Estrogen may regulate the immune function of vagina by reversing the imbalance of Th1/Th2.