The relationship between adipocyte fatty acid binding protein and lower limb vascular disease in the elderly with type 2 diabetes
10.3760/cma.j.issn.0254-9026.2014.10.013
- VernacularTitle:脂肪细胞型脂肪酸结合蛋白与老年人2型糖尿病下肢血管病变的关系
- Author:
Zhiwen LIU
;
Qiaorui LIU
;
Liming WU
;
Cong MA
;
Xulei ZHENG
;
Xudong MAO
;
Risu NA
- Publication Type:Journal Article
- Keywords:
Fatty acid binding proteins;
Diabetes mellitus,type 2;
Diabetic angiopathies;
Peripheral vascular diseases
- From:
Chinese Journal of Geriatrics
2014;33(10):1085-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between adipocyte fatty acid binding protein (A-FABP) and lower limb vascular disease (LLVD) in the elderly with type 2 diabetes(T2DM).Methods Bilateral lower limb vessels were checked by the High Resolution Color Doppler in all the subjects,including 40 healthy subjects as control (group A),126 T2DM patients.42 T2DM patients had no LLVD (group B),40 had mild LLVD (group C),and 44 had severe LLVD (group D).The levels of plasma A-FABP,blood glucose,lipid profiles,HOMA-IR,hypersensitive C reactive protein (hs CRP),and e-glomerular filtration rate were determined.Results The levels of plasma A-FABP were in the following ascending order of group A(4.5± 1.7)μg/L＜group B(6.1±2.1)μg/L＜group C (7.2 ± 2.3)μg/L ＜ group D (8.4 ± 3.2)μg/L (P＜ 0.01).A-FABP levels elevated along with the decrease of ABI and the increase of L IMT.Multiple logistic regression analysis showed that A FABP levels was main influencing factor of lower limb vascular disease (LLVD) in the elderly with type 2 diabetes.LDL C,HbA1c,HOMR-IR,hs-CRP were the predictive factors for the plasma A-FABP levels in the elderly with T2DM after multiple stepwise regression analysis.Conclusions For elder T2DM patients,the level of plasma A FABP is correlated with the degree of LLVD,and plays an important role in the progress of LLVD.
