Characteristics of early changes in serum interleukin 17 and interferon-γ levels in elderly patients with acute myocardial infarction
10.3760/cma.j.issn.0254-9026.2014.12.008
- VernacularTitle:老年急性心肌梗死患者早期白介素-17与干扰素-γ的变化特点
- Author:
Li WEN
;
Xinchao ZHANG
;
Chunyi FU
;
Jinlong LI
;
Wei WEN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Interleukin-17;
Interferon typeⅡ
- From:
Chinese Journal of Geriatrics
2014;33(12):1291-1293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of early changes in serum IL-17 and IFN-γ levels in elderly patients with acute myocardial infarction (AMI).Methods 70 hospitalized elderly patients with AMI and 35 healthy people were selected.Serum level of interleukin-17 (IL 17) and interferon-γ (IFN-γ) were assayed by enzyme linked immunosorbent assay (ELISA).Results Serum levels of IL17 and IFN-γ showed increasing trends in elderly patients with AMI as compared with that in control group,but there were no significant differences between the two group [(35.73 30.28) pg/ml vs.(28.70±17.12) pg/ml,(15.29±14.64) pg/ml vs.(11.38±10.10) pg/ml,t=0.144 and 0.138,P=0.365 and 0.377].There were correlations between serum IL-17 and IFN γ levels in patients with AMI and controls(r=0.936 and 0.989,both P=0.00).Serum levels of IL-17 or IFN-γhad no significant differences between AMI patients with well and poor prognosis [(35.43± 34.36) ng/L vs.(36.11±30.16) ng/L,(13.90±13.98) ng/L vs.(15.99±14.14) ng/L,U=0.266 and 0.166,P=0.687 and 0.668].Conclusions Serum IL-17 level has an increasing trend in AMI patients within 24h,but has no statistical significant.Serum IL 17 level has a significantly positively correlation with serum IFN γ level in the elderly,but serum levels of IL-17 or IFN γ have no significant correlations with short term prognosis in elderly patients with AMI.
