The expression of lymphoid-associated antigens in elderly patients with acute myeloid leukemia and its clinical significance
10.3760/cma.j.issn.0254-9026.2014.10.017
- VernacularTitle:淋系分化抗原在老年急性髓系白血病患者中的表达及临床意义
- Author:
Wenhui ZHANG
;
Kaikai CHI
;
Yuqing CHEN
;
Yin ZHANG
;
Kai SUN
;
Baogen MA
- Publication Type:Journal Article
- Keywords:
Leukemia,myloid,acute;
Antigens,Ly
- From:
Chinese Journal of Geriatrics
2014;33(10):1100-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of lymphoid-associated antigens in acute myloid leukemia and its clinical significance.Methods 84 patients with de nove (untreated) AML were classified by FAB classification and immunophenotype,of which 53 cases were analyzed by karyotype according to WHO standards.Patients were divided into 2 groups according to whether lymphoid antigen (Ly) was expressed or not.After all patients were treated with a standard remission-induction regimen for 1 course,bone marrow in 63 cases were re examined.Results 49 cases (58.3％) were classified into lymphoid surface antigen-positive acute myeloid leukemia (Ly+ AML) group,35 cases (42.7％) into lymphoid surface antigen-negative acute myeloid leukemia (Ly-AML) group.The incidences of hepatosplenomegaly and lymphadenopathy had significant differences between Ly+AML and Ly AML groups [55.1％ (27 cases) vs.22.9％ (8 cases),t=3.412,P=0.003].There were no significant differences in other indicators between the two groups.On the basis of equal intensity of chemotherapy,complete remission (CR) had no significant difference(x2 =1.995,P=0.158),the disease-free survival (DFS) in Ly + AML group was shorter than in Ly-AML group(t=2.427,P=0.019),the recurrence rate was higher in Ly + AML group than in Ly-AML group(x2 =4.132,P=0.044).Conclusions The expression of lymphoid associated antigens in acute myeloid leukemia is complex.Patients with Ly+AML show poor response to chemotherapy,and have poor prognosis.We should explore new chemotherapy for acute myeloid leukemia.
