Perioperative application of ambroxolin elderly smoking patients undergoing lung cancer operation
10.3760/cma.j.issn.0254-9026.2014.10.011
- VernacularTitle:盐酸氨溴索在老年肺癌吸烟患者围术期的应用
- Author:
Xin WANG
;
Lei WANG
;
Hao ZHANG
;
Huayong WANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Ambroxol
- From:
Chinese Journal of Geriatrics
2014;33(10):1078-1080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of perioperative application of ambroxol in elderly smoking patients undergoing lung cancer operation.Methods 220 long time smoker undergoing pulmonary lobectomy were randomized into two groups:the intervention group (n=112) and the control group (n =108).The intervention group received ambroxol injection 30 mg intravenously,thrice daily from five days before the surgery.The control group was given ambroxol injection 30 mg intravenously,thrice daily from one day after the surgery.The difficulty in expectoration,the nature of the sputum and the duration of antibiotic use were recorded.The postoperative lung complications and the adverse reactions of ambroxol were observed.Results There were significant differences in improvements of expectoration and the nature of the sputum on the third and seventh after operation between the intervention and control groups(x2 =6.77,6.08,8.12,12.61,P=0.034,0.049,0.017,0.002).After the surgery,the duration of antibiotic use was less in the intervention group than in the control group [(5.92 ± 0.72) d vs.(7.04 ± 0.87) d,t =10.33,P=0.000].The incidences of lung infections and atelectasis after the surgery were lower in the intervention group than in the control group [19.6％ (22/112) vs.33.3％ (36/108),6.3％ (7/112) vs.16.7％ (18/108),x2 =5.31,5.92,P=0.021,0.015].In both groups,two patients had mild nausea and vomiting (x2 =0.22,P=1.000).No other common adverse reactions of ambroxol were observed in the two groups.Conclusions Perioperative application of ambroxol can decrease the sputum viscosity,make expectoration easier and reduce the occurrence of postoperative lung complications and the duration of antibiotic use.It is worth wide application in clinical practice.
