Variations of spatial position and overlap ratio for GTV50 and IGTV of primary thoracic esophageal cancer during radiotherapy:a study based on 4DCT scans
10.3760/cma.j.issn.1004-4221.2014.06.009
- VernacularTitle:基于4DCT探讨放疗中食管癌GTV50及IGTV空间位置及重合度变化
- Author:
Jinzhi WANG
;
Jianbin LI
;
Wei WANG
;
Yingjie ZHANG
;
Yun DING
;
Tonghai LIU
;
Dongping SHANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasm/radiotherapy;
Tomography,X-ray computed,four-dimensional;
Gross tumor volume;
Degree of inclusion;
Matching index
- From:
Chinese Journal of Radiation Oncology
2014;23(6):491-494
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variations of the spatial position and overlap ratio for gross tumor volume (respiratory phase 50％) (GTV50) and internal gross tumor volume (IGTV) of primary thoracic esophageal cancer during conventional fractionated radiotherapy based on repeated four-dimensional computed tomography (4DCT) scans.Methods Thirty-three patients with thoracic esophageal cancer underwent contrast-enhanced 4DCT scans before radiotherapy and at the 10th and 20th fractions of radiotherapy.Scans were registered to the baseline 4DCT scan using bony landmarks.The GTV50 was delineated by the same radiotherapist on each 4DCT imaging data set,and the IGTV was constructed accordingly.The target volume,degree of inclusion (DI),and matching index (MI) were compared in different phases.Results The volumes of GTV50 and IGTV decreased along with treatment course.No significant changes in the centroid position were observed for the GTV50 and IGTV.The median DIs of the target volumes at the 10th and 20th fractions in the original target volume were 0.75 and 0.63(P =0.000) for GTV50 and were 0.79 and 0.66(P=0.000) for IGTV,while the median MIs were 0.61 and 0.56(P=0.002) for GTV50 and were 0.68 and 0.58 (P =0.005) for IGTV.A positive correlation between the variation of volume ratio and the variation of DI was found for GTV50 and IGTV (r =0.632,r =0.783),and the variation of volume ratio was also positively correlated with the variation of MI (r =0.387,r =0.483) ;the 3D vector was negatively correlated with the MI (r =-0.455,r =-0.438).Conclusions During conventional fractionated radiotherapy,the variation of spatial position is less than 0.8 cm for GTV50 and IGTV of primary thoracic esophageal cancer,and the decline of the target leads to varying degrees of decreases in DI and the MI.
