Readout segmentation of long variable echo-trains: a preliminary study regarding the diagnosis of prostate cancer
10.3760/cma.j.issn.1005-1201.2014.10.012
- VernacularTitle:分段读出扩散加权成像序列表观扩散系数在前列腺癌鉴别诊断中的价值
- Author:
Zhaoyan FENG
;
Liang WANG
;
Xiangde MIN
;
Liang LI
;
Jie CAI
;
Ming DENG
;
Peilei ZHU
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Prostatic hyperplasia;
Magnetic resonance imaging
- From:
Chinese Journal of Radiology
2014;48(10):841-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of readout segmentation of long variable echo-trains (RESOLVE) in the differentiation of prostate cancer from benign prostatic hyperplasia (BPH).Methods Seventy two consecutive patients with suspected prostate cancer were evaluated by 3.0 T MR examination (RESOLVE sequence included,b values=0 and 800 s/mm2) were included in our retrospective study.All the patients had ultrasound guided systemic biopsy with histopathological diagnosis.The patients were divided into group A (23 prostate cancer cases with total 43 malignant lesions) and group B (49 BPH cases with total 64 benign lesions).Two radiologists who were blinded to the clinical data quantitatively analyzed the ADC values of suspicious lesions independently.Inter-reader agreement for ADC values was assessed with Bland and Altman test,and the intra-class correlation coefficient (ICC).Difference of ADC values in two groups was assessed by student's t test.Receiver operating characteristic curve (ROC) was used to determine the best predictor and cutoff value.Results A total of 107 lesions (43 malignant and 64 benign) were identified in 72 patients.ICC was 0.976,P＜0.01.The mean ADC value of prostate cancer is lower than BPH (t=19.223,P＜0.01),(0.74±0.12) × 10 3 and (1.21±0.12) × 10-3mm2/s respectively.Diagnostic cut-off point was 0.946× 10-3mm2/s,diagnostic sensitivity 95.3 ％ (41/43),specificity 98.4％ (63/64),accuracy 97.2％ (104/107).Conclusion RESOLVE ADC value is valuable in the differential diagnosis of prostate cancer and BPH.
