Diagnostic value of non-invasive imaging modalities to evaluate lower limb arterial disease associated with diabetes
10.3760/cma.j.issn.1005-1201.2015.01.006
- VernacularTitle:无创影像检查方法诊断糖尿病下肢动脉病变的价值
- Author:
Qiang HUANG
;
Jianfeng WANG
;
Renyou ZHAI
;
Yang ZHANG
;
Weili YANG
;
Baojie WEI
;
Kun GAO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Arteries;
Angiography,digital subtraction;
Tomography,X-ray computed;
Magnetic resonance angiography;
Ultrasonography
- From:
Chinese Journal of Radiology
2015;49(1):20-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of non-invasive imaging modalities to evaluate lower limb arterial disease associated with diabetes.Methods Two hundred and twenty seven patients (292 lower limb arteries) with lower limb arterial disease due to diabetes underwent both DSA and one of the pre-operative imaging modalities including CTA,CE-MRA and DUS were included in this study.The diagnostic consistency of CT angiography(CTA),contrast enhanced magnetic resonance angiography (CE-MRA) and Doppler ultrasonography(DUS) compared with DSA were calculated respectively.CTA was performed in 169 lower limb arteries,while 123 in CE-MRA and DUS in 192.DSA was used as the gold standard.Consistency analysis was performed to evaluate the three imaging modalities with lower limb artery classified as Grade 1,Grade 2 and Grade 3.Results The sensitivity of CTA to evaluate mild stenosis in Grade 1 to Grade 3 was 100％(56/56),97.6％(82/84) and 93.8％(30/32) respectively,while 100％(19/19),94.4％ (34/36)and 61.5％ (8/13) for severe stenosis.The diagnostic accuracy of mild and severe stenosis was 95.9％ (162/169) to 99.4％ (168/169),which showed good consistency with the result of DSA with Kappa value of 0.760 to 0.916,and P＜0.05.The sensitivity of CE-MRA to evaluate mild stenosis in Grade 1 to Grade 3 was 93.2％(68/73),97.2％(103/106) and 93.2％ (69/74)respectively,while 91.3％ (21/23),80.8％ (42/52)and 42.1％ (8/19)for severe stenosis.The diagnostic accuracy of mild and severe stenosis was 86.2％ (106/123) to 96.7％ (119/123),which showed good consistency with the result of DSA with Kappa value of 0.767 to 0.868 and P＜0.05.The sensitivity of DUS to evaluate mild stenosis in Grade 1 to Grade 3 was 89.9％ (62/69),88.8％ (87/98) and 79.2％ (42/53) respectively,while 73.1％ (19/26),84.8％ (39/46) and 44.4％ (8/18) for severe stenosis.The diagnostic accuracy of mild and severe stenosis was 89.7％ (174/194) to 93.8％ (182/194),which showed good consistency with the result of DSA with Kappa value of 0.476 to 0.864 and P＜0.05.Conclusions The non-invasive imaging modalities,namely CTA,CE-MRA and DUS all have good diagnostic consistency compared with DSA.CTA is superior to CE-MRA and DUS in evaluating the severe stenosis of lower limb arterial disease in diabetes patients.
