A voxel-based morphometry study of gray matter abnormalities in patients with hypothyroidism
10.3760/cma.j.issn.1005-1201.2014.12.006
- VernacularTitle:采用基于体素的形态测量学方法分析甲状腺功能减退患者全脑灰质形态变化
- Author:
Yi ZHANG
;
Wei ZHANG
;
Lingheng SONG
;
Huiping ZHANG
;
Shuhua RAN
;
Bing CHEN
;
Haitao LI
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Magnetic resonance imaging;
Brain
- From:
Chinese Journal of Radiology
2014;48(12):987-991
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the gray matter volume differences between adult hypothyroid subjects and healthy controls using voxel-based morphometry (VBM).Methods A total of 28 untreated hypothyroid patients and 28 age and gender-matched uormal controlswere recruited.The coucentrations of their freetriiodothyronine (FT3),free theroxine (FT4),and thyroid stimulating hormone (TSH)were testedfrom their venous blood on the day they accepted MR scanning.High resolution 3D-datawereobtained using 3.0 T MRI scanner.VBM analysis was performed to detect the volume differences between the groups by using voxel-wise two sample t test.Multiple regression analysis was employed to analyze the influence exerted upon gray matter volume by serum FT3,FT4,and TSH concentrationof hypothyroid patients.Results Compared to controls,gray matter volumes in the bilateral superior frontal gyri,left precentralgyrus and bilateral cerebellum were decreased in hypothyroid patients (voxels 211-2 142,t=3.36-3.69,P＜0.01,corrected).No significant correlation between the gray matter volume in the above-mentioned brain regions and the clinical variables (serum FT3,FT4,and TSH concentration) (P＞0.05) was found in the multiple regression analysis.Conclusions VBM analysis revealed that hypothyroid patients exhibited reduced gray matter volume in multiple brain regions.It suggests that the lack of thyroid hormones can lead to the structural abnormalities in adult brain and selective gray matter atrophy in multiple brain regions.
