Immunity function changes of zonisamide treatment on epilepsy children
10.3760/cma.j.issn.1008-6315.2015.06.008
- VernacularTitle:新型抗癫痫药物唑尼沙胺治疗癫痫儿童免疫功能的变化
- Author:
Fang CHEN
;
Suzhen SUN
;
Lihui WANG
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
Zonisamide;
Epilepsy;
Children;
Immune function
- From:
Clinical Medicine of China
2015;31(6):506-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the immune function changes of zonisamide treatment as a new antiepileptic drug monotherapy on epileptic children.Methods Forty children with epilepsy (25 girls and 15 boys,aged from 1 to 6 years old) were enrolled in the Children' s Hospital of Hebei Province as our subjects and they were followed 3 and 6 months after treatment.The venous blood sample was collected respectively from the children on empty stomach.Applying automatic biochemical analyzer to detect serum immunoglobulin.IgG,IgA,IgM through immune turbidimetry methods.While CD3,CD4,CD8 were detected through the application of flow cytometry.Results Compared with the healthy control group,IgA,IgG,CD8 levels increased and the level of CD3,CD4 decreased in epileptic children and there were significant differences (F=160.94,262.66,539.09,634.36,164.27;P＜0.05).The level of IgM between epilepsy group and control group did not showed difference (P＞0.05).After 3 months and 6 months treatment of zonisamide,the level of IgA,IgG,CD8 were decreased,while CD3,CD4 levels increased than those in epilepsy group before treatment (P＜ 0.05).Conclusion Zonisamide may play a role of the antiepileptic mechanism by improving children' s immune function.
