Impacts of mecobalamin on plasma inflammatory factors and carotid artery plaques in patients with H type hypertension
10.3760/cma.j.issn.1008-6315.2015.01.010
- VernacularTitle:甲钴胺对H型高血压患者血浆炎性因子及颈动脉斑块的影响
- Author:
Feng YANG
;
Minwang GUO
;
Rujuan ZHOU
;
Longjin HE
;
Xiaorong WANG
- Publication Type:Journal Article
- Keywords:
Mecobalamin;
H type hypertension;
Plasma inflammatory factors;
Carotid artery plaque
- From:
Clinical Medicine of China
2015;31(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impacts of mecobalamin on plasma inflammatory factors (plasma high-sensitivity C-reactive protein (Hs-CRP) and carotid artery plaques in patients with H type hypertension.Methods Forty-eight acute ischemic stroke patients who were diagnosed with H type hypertension in the People's Hospital of Taixing were collected,and they were randomly divided them into treatment group and control group,and 24 cases of each group.Patients in both groups were given conventional therapies,including treatment of anti platelet aggregation,plaque stability and reduced plaque treatment.While patients in the treatment group were given additional oral drug of mecobalamin,500 μg each time,three times a day,6 months in all.Each case was evaluated at the second day of hospitalization,four weeks later,eight weeks later,three months and sixth months later.The examination items involved included level of plasma homocysteine(Hcy),level of hsCRP and conditions of carotid artery plaques under ultrasonography.Results Aafter four weeks,eight weeks,three months and sixth months therapy,there were significant differences between treatment group and control group in terms of Hcy (t =4.049,3.896,6.052,6.159 ; P ＜ 0.05) and the level of hs-CRP (t =37.249,28.376,26.454,0.522P ＜ 0.01).Afrter three months and sixth months therapy,compared to the control group,the carotid artery plaques were obviously reduced,and the differences were statistically significant (t =2.309,2.434 ; P ＜ 0.05).Conclusion Mecobalamin can reduce the level of plasma homocysteine,then lead to reductions of levels of plasma inflammatory factors and volume of carotid artery plaques.
