Expression and significance of p15, p16, p21 in Uygur patients with psoriasis in Xinjiang

VernacularTitle:新疆维吾尔族银屑病患者皮损中p15、p16、p21蛋白表达及意义
Author: Huiqin WANG ; Xinmei LIU ; Xiujuan WU ; Weidong WU
Publication Type:Journal Article
Keywords: Psoriasis/PA/ME; Skin/PA/ME; Genes,p16; Oncogene protein p21 (ras)/ME
From: Journal of Chinese Physician 2015;17(5):692-694
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions of p15,p16,and p21 in skin of uygur patients with psoriasis and its significance in the development of psoriasis.Methods The expressions of p15,p16,and p21 were studied with immunohistochemical method in the Xinjiang Uygur psoriatic and normal Uygur skins.Results The positive expression rate of p16 gene was 12.5％ in skin lesions of patients with psoriasis Uygur,and 66.67％ in the normal group.The positive expressions of p15,and p21 genes in skin lesions of patients with psoriasis and healthy Uygur population were higher.Conclusions There is a significant correlation between the development of uygur psoriasis vulgaris and abnormal expression of p16.