The relationship between genetic single-nucleotide polymorphisms of LIG4 and HSPB1 and prognosis in nasopharyngeal carcinomas

VernacularTitle:LIG4及HSPB1基因单核苷酸多态性与鼻咽癌预后的关系
Author: Dan LIU ; Yanli QU ; Yuxia ZHAO ; Hong YU ; Ya GAO ; Ying CHEN
Publication Type:Journal Article
Keywords: Nasopharyngeal neoplasms/GE; DNA ligases/GE; Heat-shock proteins/GE; Prognosis
From: Journal of Chinese Physician 2015;17(5):678-681
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between genetic single-nucleotide polymorphisms of ligase Ⅳ (LIG4) and heat shock protein B1 (HSPB1) and prognosis in nasopharyngeal carcinomas.Methods DNAs were extracted by phenol-chlorofrom method from peripheral blood samples of 168 nasopharyngeal carcinoma patients.Genetic single-nucleotide polymorphisms were divided by Taqman realtime polymerase chain reaction (PCR).All statistical analyses were performed with statistical product and service solutions v13.0.A p-value of less than 0.05 was confirmed as statistical significance.Single-factor and multiple-factor logistic analyses were used to calculate odds ratio (OR) and 95％ confidence interval (CI).Long-rank test and COX were also used.Results No relationship was found between the recurrence,metastasis and overall survival of nasopharyngeal carcinoma and genetic single-nucleotide polymorphisms of LIG4 and HSPB1 with single-factor and multiple-factor logistic analyses.Conclusions LIG4 rs1805388 and HSPB1 rs2868371 had no relationship with prognosis of nasopharyngeal carcinomas.