Hyperglycemia in patients with primary aldosteronism

VernacularTitle:原发性醛固酮增多症患者高血糖患病情况研究
Author: Yuqing ZHOU ; Shuling HUANG ; Min MAI ; Jinshun ZHENG ; Zuanyi ZHONG
Publication Type:Journal Article
Keywords: Hyperaldosteronism/CO; Hyperglycemia/CO/EP; Prevalence
From: Journal of Chinese Physician 2015;17(4):548-550
CountryChina
Language:Chinese
Abstract: Objective To investigate the prevalence of hyperglycemia in patients with primary aldosteronism.Methods Thirty two patients diagnosed as primary aldosteronism(PA) in our hospital from 2010 to 2013 (PA group),and 40 patients as essential hypertension (EH group).Two groups were measured and compared,including blood pressure,plasma aldosterone,urine aldosterone,and plasma potassium.Oral glucose tolerance test (OGTT) was performed and homeostasis model assessment-insulin resistance index(HO-MA-IR) were calculated.Results The prevalence of hyperglycemia was 43.75％ in PA group,including 25％ patients of glucose intolerance and 18.75％ patients of diabetes mellitus,which was significantly higher than those of EH group (25％,12.5％,and 12.5％,respectively).PA group's fasting and 2-hour postprandial insulin levels and insulin resistance index were higher than that of EH group.Conclusions The present study indicated that patients with PA had a significantly high prevalence of glucose metabolism disturbance and insulin resistance.Screening test should be performed and avoid missed diagnosis.