Relationships between serum inflammatory mediators and myocardial injury in sepsis rats
10.3760/cma.j.issn.1008-1372.2015.04.011
- VernacularTitle:脓毒症大鼠血中炎症介质水平和心肌损伤的关系
- Author:
Dan LIU
;
Bing XIANG
- Publication Type:Journal Article
- Keywords:
Sepsis/ME/PA/CO;
Cardiomyopathies/CO/ME;
Tumor necrosis factor-alpha/ME;
Interleukin-6/ME;
Troponin Ⅰ/ME;
Natriuretic peptide,brain/ME;
Lactic acid/ME
- From:
Journal of Chinese Physician
2015;17(4):516-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships between serum inflammatory mediators and myocardial injury in rats with sepsis.Methods Thirty male Sprague Dawley (SD) rats were randomly divided into normal control group and sepsis (0,24,48,72 h) groups.The rats subjected to sepsis were induced with cecum ligation perforation (CLP).Tumor necrosis factor alpha (TNF-α),interleukin-6 (IL-6),cardiac troponin Ⅰ (cTnI) and B-type natriuretic peptide precursor (NT-proBNP) in the venous blood were measured at 0 h,24 h,48 h,and 72 h after CLP.The lactic acid (Lac) of the arterial blood,cardiac index (CI),acute physiology and chronic health evaluation (APACHE) Ⅱ score were also determined simultaneously.Results The levels of TNF-α,IL-6,cTnI,NT-proBNP,and Lac in sepsis (24 h,48 h,and 72 h) groups were significantly elevated compared to normal control and sepsis (0 h) group.In addition,the number of sepsis (24 h,48 h,and 72 h) groups progressively increased (P ＜0.05).Conclusions It existed a close relationship between serum inflammatory mediators and myocardial injury,and made myocardium damage after CLP.
