Clinical study on the effect of preemptive anti-cytomegalovirus therapy on prognosis of patients with acquired immunodeficiency syndrome and cytomegalovirus viraemia
10.3760/cma.j.issn.1008-1372.2015.04.009
- VernacularTitle:先占性抗巨细胞病毒治疗影响艾滋病合并巨细胞病毒血症患者预后的临床研究
- Author:
Ying WEN
;
Yu WANG
;
Ying ZHOU
;
Pei LIU
- Publication Type:Journal Article
- Keywords:
Cytomegalovirus infections/DT;
Antiviral agents/TU;
Acquired immunodeficiency syndrome/CO/TH;
Viremia/CO/TH;
Prognosis
- From:
Journal of Chinese Physician
2015;17(4):509-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of preemptive anti-cytomegalovirus therapy on prognosis of patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus (CMV) viraemia.Methods A non-random prospective study of male hospitalized patients were carried out who were newly diagnosed as AIDS during July 1,2011 to June 30,2013 in the First Affiliated Hospital of China Medical University.There were 69 patients who were divided into treatment group (57 cases) and control group (12cases).The duration of anti-cytomegalovirus therapy was a week after plasma CMV-DNA becoming undetectable.Baseline age,CMV-DNA,human immunodeficiency virus (HIV)-RNA,CD4+T cells,the rate of pneumocystis carinii pneumonia (PCP) and tuberculosis were evaluated between two groups.After 12-month follow-up,CD4 + T cells,the rate of rehospitalization,CMV retinitis,and mortality were evaluated.Results There were no difference in CMV-DNA,HIV-RNA,CD4 + T cells,the rate of PCP,and tuberculosis(P ＞ 0.05).At the end of 12 months,there were higher CD4 +T cells and lower rehospitalization rate in treatment group than control group(t =-3.850,P ＜ 0.05;x2 =6.078,P ＜ 0.05).CMV retinitis was not found.The mortality was not different between two groups(P ＞0.05).Conclusions Anticytomegalovirus therapy was beneficial to the increment of CD4 +T cells and decrement of rehospitalization,and prevention from CMV retinitis.
