Expressions of HPV16E6 and E-cadherin in different cervical tissues and its interaction with clinical pathological features
10.3760/cma.j.issn.1008-1372.2015.07.012
- VernacularTitle:HPV16E6与E-钙黏蛋白在不同宫颈病变组织中的表达与临床病理特征的相关性
- Author:
Meihua LI
;
Lesai LI
;
Yile CHEN
- Publication Type:Journal Article
- Keywords:
Human papillomavirus 16/ME;
Cadherins/ME;
Uterine cervical neoplasms/ME;
Cervical intraepithelial neoplasia/ME;
Cervix uteri/CY/ME
- From:
Journal of Chinese Physician
2015;17(7):995-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of human papillomavirus (HPV) 16E6 and E-cadherin in different cervical tissues.Methods Immunohistochemistry expressions of HPV16E6 and E-cadherin were analyzed in 30 normal cervical tissues,34 cervical intraepithelial neoplasias (CIN),and 60 squamous cervical cell carcinomas.Results The differences in positive expression rates of HPV16E6 and E-cadherin were statistically significant among normal cervical tissues,CIN Ⅰ,CIN Ⅱ-Ⅲ,cervical squamous cell carcinomas (x2 =40.166,P =0.000;x2 =31.295,P =0.000),respectively.The abnormal expressions of HPV16E6 and E-cadherin expression were significantly related to clinical pathological stage,tumor size,histological grade,invasion depth of squamous cervical cancers (P ＜ 0.05),but not correlated with age (P ＞0.05).The expressions between HPV16E6 and E-cadherin protein were negatively correlated (rs =-0.647,P =0.000).Conclusions There may be relationship between HPV16E6 and E-cadherin,and the abnormal expressions of two proteins may be associated with poor prognosis of cervical carcinomas.
