Clinical value of combined detection of serum CA724, CEA and TNF-α for advanced gastric cancer
10.3760/cma.j.issn.1008-1372.2015.07.011
- VernacularTitle:血清CA724、CEA、TNF-α联合检测对进展期胃癌诊疗的临床价值
- Author:
Zonglin LI
;
Huaiwu JIANG
;
Dong XIA
;
Qing LIU
;
Tuping GONG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms/DI/TH/ME;
Antigens,tumor-associated,carbohydrate/ME;
Carcinoembryonic antigen/ME;
Tumor necrosis factor-alpha/ME
- From:
Journal of Chinese Physician
2015;17(7):992-994
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of combined detection of serum carbohydrate antigen 724 (CA724),carcinoembryonic antigen (CEA),and tumor necrosis factor-α (TNF-α) for the diagnosis,assessment of curative effect,and illness monitoring for advanced gastric cancer (AGC).Methods Serum levels of CA724,CEA and TNF-α were measured by the methods of chemiluminescence and compared in 20 patients with AGC (Group A),20 patients with benign gastric disease (Group B),and 20 healthy adults (Group C).Also,serum levels of CA724,CEA and TNF-α in peripheral blood as well as in portal vein were measured and compared before and after surgical treatment in patients of group A.Results The serum levels of CA724,CEA and TNF-α in patients of group A were significantly higher than groups B and C (P ＜ 0.05).In addition,the serum levels of CA724,CEA and TNF-α in patients of group A were decreased after surgical treatment and increased slightly after one month (P ＜ 0.05).Conclusions The serum levels of CA724,CEA and TNF-α in most patients of AGC are significantly elevated and the combined detection of serum CA724,CEA and TNF-α contributes to the diagnosis,assessment of curative effect,and illness monitoring for AGC.
