The effect of urinary kallidinogenase on serum concentrations of hydrogen sulfide, neuron-specific enolase, and S100β in patients with cerebral infarction
10.3760/cma.j.issn.1008-1372.2015.07.006
- VernacularTitle:尤瑞克林对脑梗死患者血清H2S、神经元特异性烯醇化酶与S100β浓度的影响
- Author:
Qian ZHAO
;
Shuning SUN
;
Shuyan ZHANG
;
Rubo SUI
- Publication Type:Journal Article
- Keywords:
Tissue kallikreins/TU;
Brain infarction/DT/ME;
Phosphopyruvate hydratase/ME;
Hydrogen sulfide/ME;
S100 proteins/ME
- From:
Journal of Chinese Physician
2015;17(7):974-977
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of urinary kallidinogenase on serum concentrations of hydrogen sulfide (H2S),neuron-specific enolase (NSE),and S100β in patients with cerebral infarction (CI).Methods From June 2011 to June 2014,80 patients with CI were chosen as study objectives.All patients were divided into two groups:40 patients in study group (urinary kallidinogenase group),and 40 patients in control group.The death rate,the rate of complication and National Institute of Health Stroke Scale (NIHSS) were compared between two groups.The concentrations of H2S,NSE,and S100βwas compared between two groups.Results In study group,the death rate was 5.00％ (2/40),the rate of complication was 22.50％ (9/40);in control group,the death rate was 12.50％ (5/40),the rate of complication was 15.00％ (6/40);and no significant significance was found between two groups (P ＞ 0.05).The NIHSS was (11.2 ± 3.2) in the study group,and (15.7 ± 2.7) in the control group,with statistically significant difference between two groups (P ＜ 0.05).After treatment,the concentrations of H2 S,NSE,and S100β of two groups were decreased significantly (P ＜0.05).At 1w,2w,and 3w,the concentrations of H2S,NSE and S100βhad statistically significant difference between two groups (P ＜ 0.05).Conclusions Urinary kallidinogenase has a cerebral protective effect,which can decrease the concentration of H2S,and increase the concentrations of NSE and S100βin CI patients.
