Serum vaspin levels in type 2 diabetic patients are associated with the severity of lower limb vascular lesion
10.3760/cma.j.issn.1008-1372.2015.06.021
- VernacularTitle:2型糖尿病患者血清Vaspin水平与下肢血管病变严重程度的关系
- Author:
Zhenzuo LI
;
Lin LI
;
Xiaoxia PAN
;
Li ZHANG
;
Hongzhuan LI
;
Li CHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2/ME/CO;
Serine proteinase inhibitors/ME;
Diabetic angiopathies/ME;
Lower extremity/BS
- From:
Journal of Chinese Physician
2015;17(6):879-882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between serum vaspin levels and the severity of the lower extremity vascular lesions in type 2 diabetes mellitus (T2DM) patients.Methods According to the lower extremity artery plaque,stenosis and intima-media membrane thickening severity score,92 cases of T2DM patients were divided into three groups:simple diabetes group (DM1 group) (32 cases),mild diabetic lower limb vascular lesion group (DM2 group) (33 cases),and moderately severe diabetic lower limb vascular lesion group (DM3 group) (27 cases).Twenty-six age-and gender-matched apparently healthy controls (control group) were recruited as well.Systolic blood pressure (SBP),ankle-brachial index (ABI),insulin resistance index (HOMA-IR),and other indicators were determined,serum vaspin was measured by enzyme-linked immunosorbent assay.Results After adjustment for age and gender,the DM1 group had a significantly higher serum vaspin level than control group (P ＜0.01),while for the DM2 and DM3 groups,serum vaspin levels were significantly lower than the DM1 group (P ＜ 0.01).Partial correlation analysis showed that serum vaspin was inversely associated with HOMA-IR (r =-0.461,P =0.001)and positively correlated with ABI (r =0.462,P =0.001).Logistic regression analysis demonstrated that SBP,ABI and fasting serum vaspin levels were significantly associated with the presence of the lower extremity vascular lesions in type 2 diabetes.Conclusions Serum vaspin levels were significantly elevated in simple type 2 diabetic patients while the reduction of its level might be associated with the formation of lower extremity vascular lesions in type 2 diabetic patients.
