Expression and prognostic significance of interleukin-36α in colorectal cancers
10.3760/cma.j.issn.1008-1372.2015.05.004
- VernacularTitle:白介素36α在结直肠癌中的表达及生存预测价值
- Author:
Xutao LIN
;
Dejun FAN
;
Yifeng ZOU
;
Xiaosheng HE
;
Xiaobin ZHENG
;
Xuanhui LIU
;
Ping LAN
- Publication Type:Journal Article
- Keywords:
Interleukin-1/AA/ME;
Colorectal neoplasms/ME;
Prognosis
- From:
Journal of Chinese Physician
2015;17(5):652-657
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and prognostic significance of Interleukin-36α (IL-36α) in colorectal cancer.Methods The expression of IL-36α was tested by immunohistochemical staining in 329 cases of colorectal cancer.According to the intensity and the proportion of positive tumor cells,all the patients were divided into IL-36α low and high expression groups.The clinicopathological factors and prognosis of patients between IL-36α low high expression groups were compared.Results Significant differences were observed in the number of patients in tumor differentiation and pM classification between patients in the IL-36α low and high expression groups (P ＜ 0.05).The 5-year overall and tumorfree survival rates of patients were 79.3％ and 77.2％ in IL-36α low expression group,and 66.3％ and 65.3％ in IL-36α high expression group (P ＜0.05).COX proportional hazard regression model revealed that high expression of IL-36α was associated with short overall survival time and tumor-free survival time of colorectal cancer patients (P ＜ 0.05).Multivariate analysis identified IL-36α expression in colorectal cancer as an independent prognosticator (P ＜ 0.05).Conclusions High expression of IL-36α was correlated with tumor differentiation and pM classification of colorectal cancers,and it is an independent predictor of poor survival for patients with colorectal cancer.
