Relationship between regional homogeneity of male depressed patients and the severity of depression: a resting-state fMRI study
10.3760/cma.j.issn.1674-6554.2015.05.013
- VernacularTitle:男性抑郁症患者静息态脑区局部一致性特征及其病情程度的相关性
- Author:
Qiuxiang WEI
;
Zhijian YAO
;
Rui YAN
;
Maobin WEI
;
Lingling HUA
;
Qing LU
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Gender;
Resting-state;
ReHo;
Severity of depression
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(5):435-437
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the regional homogeneity (ReHo) feature of the spontaneous neural activity within young male depressed patients,and conduct correlation analysis of the abnormal regions with the severity of depressive symptoms.Methods 19 male depressed patients and 19 educated age-matched male healthy controls were undergone resting-state functional magnetic resonance imaging scanning at 3.0 Tesla.The whole brain' s regional homogeneity was calculated.The ReHo values of abnormal brain regions after alphasim correction were conducted correlation analysis with the total score of Hamilton Rating Scale for Depression.Results As compared with the controls,the depressed patients exhibited significantly increased ReHo in the bilateral parahippocampal (-30,-42,-9:K=43:27,-33,-12:K=18) and the right posterior cingulate gyrus(3,15,33:K=54),while decreased ReHo in the right postcentral gyms (27,-36,54,K =21) (P＜0.05,Alphasim).The correlation analysis showed that the ReHo of the right parahippocampal gyrus was positively correlated with the HAMD17 total scores (r=0.535,P=0.018).Conclusions The male depressed patients exhibit abnormities in the limbicrelated brain regions during rest,and the extent of damage is correlated with the severity of depression.
