A systematic review of neuron synaptic plasticity in hioppocampus in the pathogenesis of depression
10.3760/cma.j.issn.1674-6554.2015.05.010
- VernacularTitle:海马神经元突触可塑性在抑郁症发病机制中的研究
- Author:
Cong LIU
;
Jinhong HAN
;
Changhong WANG
- Publication Type:Journal Article
- Keywords:
Depression;
Hippocampus;
Neuron;
Synapse;
Plasticity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(5):423-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the neuron synaptic plasticity in hioppocampus in the pathogenesis of depression in present studies,and expected to provide reference and basis for study of depression in clinic and model.Methods The wordsdepression, antidepression, chronic unpredictable stimulate, hippocampus, synapse,plasticity were used as index words.Analysis the relationship of depression or antidepression and synaptic plasticity in hippocampus from the results of researches enrolled at home or abroad.Summarize the effect of neuron synaptic plasticity in hioppocampus in the pathogenesis of depression.Result Totally 37 articles enrolled.They show the onset of depression or antidepressant processes always combine with the damage or recover of neuron synaptic plasticity.Conclusion The reduction or damage in synaptic plasticity in hippocampus is likely to be the pathogenesis of depression,like the changes of function or expression of SYN-1,MAP-2,SYT-1,PSD-95 or any other synapse-associated proteins.Meanwhile,studies of using enrich environment to treat depression indicated that depression is likely related to the synaptic plasticity in hippocampus in another way.But who are the synapse-associated proteins related to synaptic plasticity in depression? How to design the enrich environment.? These still need further study.
