A clinical outcomes of duloxetine in the treatment of malignant neuropathic pain with depression
10.3760/cma.j.issn.1674-6554.2015.04.020
- VernacularTitle:度洛西汀治疗癌性神经病理性疼痛伴抑郁患者的临床疗效
- Author:
Jie SHANG
;
Yulong CHEN
;
Jing WANG
;
Jichun HU
- Publication Type:Journal Article
- Keywords:
Duloxetine;
Malignant neuropathic pain;
Depression
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(4):350-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of duloxetine in the treatment of malignant neuropathic pain with depression.Methods 60 patients were randomly divided into two groups as study group(30 cases) and contrdl group(30 cases) and treated for 4 weeks.The patients of study group were treated with duloxetine and oxycontin,and the patients of control group were treated with oxycontin only.Numberical rating scale (NRS) on pain,criteria of pain relief and Hamilton depression scale(HAMD,17 items) score were used to assess the therapeutic effect before and after treatment.Results By the end of the fourth week of treatment,the average usage of oxycontin of the study group was significantly less than control group((45.6±8.5) mg vs (88.2±5.2)mg,P＜0.05).The effective rate of pain relief in the study group was significantly higher than that in control group (93.3％ vs 73.3％,P＜0.05).Comparing pre-treatment,the score of HAMD of the study group had a remarkable decrease ((11.45±4.56) vs (23.07±5.47),P＜0.01).In comparison to the score of control group,study group had a significant effect ((11.45±4.56) vs (18.75±4.21),P＜0.01).Conclusion Duloxetine is one of effective agents in the treatment of malignant neuropathic pain with depression,which can alleviate depression and relieve pain.Duloxetine have mild adverse effects and good tolerance.
