Analysis about strategies on lung protection of ventricular septal defect infants during perioperation

VernacularTitle:婴幼儿室间隔缺损围术期的肺保护策略
Author: Bin LI ; Kaiyuan WU ; Taibing FAN
Publication Type:Journal Article
Keywords: Ventricular septal defect; Cardopulmonary bypass; Lung injury; Perioperation
From: Chinese Journal of Thoracic and Cardiovascular Surgery 2015;31(3):158-160
CountryChina
Language:Chinese
Abstract: Objective Approach to safe and effective lung protection strategies on ventricular septal defect infants during perioperation.Methods There were 4 groups as blank control group,ambroxol group,methylprednisolone group and ulinastatin group.We tried to find a safe and effective stratege on lung protection by comparing each other on the respiratory function indexes and inflammation biomarkers.Results Postoperation of VSD repair,respiratory function indexes such as Ppeak,oxygenation index inspiratory resistance and mechanical ventilation time were significantly different (P ＜ 0.05) among the 4 groups.The inflammation biomarkers such as WBC,CRP and PCT had no differences the first day(P ＞0.05),and were statistically significant the third day (P ＜ 0.05).Conclusions Ambroxol,methylprednisolone and ulinastatin all are effective drugs for lung protection.Considering about the clinical curative effect and side effects,ambroxol is more safe and effective relatively.