Retrospective analysis of induction concurrent chemoradiotherapy with weekly docetaxel and cisplatin followed by surgery for stage ⅢA-N2 non-small-cell lung cancer
10.3760/cma.j.issn.1001-4497.2015.01.001
- VernacularTitle:诱导同步放化疗联合手术治疗ⅢA-N2期非小细胞肺癌——基于多西他赛与顺铂每周方案的疗效观察
- Author:
Guanchao JIANG
;
Xiuyuan CHEN
;
Yun LI
;
Fan YANG
;
Hui ZHAO
;
Jun WANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small lung;
Surgical treatment;
Antineoplastic chemothrapy protocols;
Treatment outcome
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2015;31(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of induction concurrent chemoradiation therapy with weekly docetaxel and cisplatin(DP) for stage Ⅲ A-N2 lung cancer.Methods Eighteen patients diagnosed of stage Ⅲ A-N2 NSCLC in our center were enrolled from March,2011 to November,2013.The induction regimen consisted of 5 cycles of docetaxel(20 mg/m2) and cisplatin(20 mg/m2) administered intravenously on days 1,8,15,22 and 29 with concurrent thoracic radiotherapy in fractions of 1.8Gy,to a total dose of 45Gy.Patients proceeded to surgery,if no progressive disease occurred,followed by adjuvant chemotherapy with DP strategy.Results Eighteen patients were enrolled and 12 underwent surgery.The tumor response for the induction therapy was 1 CR,10 PRs,6 SDs and 1 PD.Five of 18 patients presented with level 3 or above adverse effects,among which were 2 neutropenia,1 liver toxicity,1 anemia and 1 lymph node infection.The median operation time was 290 min,intraoperative blood loss was 350 ml,length for postoperative drainage was 5 d,and time to discharge was 7 d.The mediastinal lymphnodedownstaging rate was 50％ (3 pN0 cases and 3 pN1 ones),92％ of the operated patients reached complete resection.One-year survival was 75.9％ and 1-year progression free survival was 49.2％.Conclusion Weekly docetaxel and cisplatin strategy in induction concurrent chemoradiotherapy for stage Ⅲ A-N2 NSCLC patients has been validated to be safe and effective.
