PRGD composite nerve conduit in repair of human peripheral nerve defect in upper extremity
10.3760/cma.j.issn.1001-2036.2015.02.008
- VernacularTitle:PRGD复合神经导管修复上肢周围神经缺损
- Author:
Jifeng HUANG
;
Weicai ZHANG
;
Weili WANG
;
Li LIN
;
Qiongjiao YAN
;
Shipu LI
- Publication Type:Journal Article
- Keywords:
Nerve conduit;
Peripheral nerve defect;
Repair;
Upper extremity;
RGD peptide modified poly { (lactic acid)-co-[(glycolic acid)-alt-(L-lysine)] } (PRGD)
- From:
Chinese Journal of Microsurgery
2015;38(2):130-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of PRGD composite nerve conduit in the treatment of human large-diameter,critical peripheral nerve defect in upper extremity.Methods From December,2011 to August,2014,19 patients with large-diameter,critical peripheral nerve defect in upper extremity were treated with PRGD composite nerve conduit.The patients were followeded-up periodically.The sensory and motor function recovery,high frequency ultrasound,and EMG were employed to assess the efficacy.Results The patients were followed up for an average time of 12-32 months(mean 21.75 ± 6.86 months),sensory and motor function recovered excellent in 7 patients,satisfactory in 7 patients,tolerable in 3 patients and no improvement in 2 patients were obtained according to the peripheral nerve function assessment standard built by British medical research council,the rate excellent and satisfactory results was 73.7％.Conclusion It is clinically promising to use PRGD composite nerve conduit to repair large-diameter,critical peripheral nerve defect in upper extremity,thus laying a foundation for its further application in clinical practice.
