Relationship between genetic variants in the Toll-like receptor pathway genes and susceptibility of gastric cancer and esophageal squamous cell carcinoma
10.3760/cma.j.issn.0254-1432.2015.03.008
- VernacularTitle:Toll样受体通路基因的遗传变异与胃癌及食管鳞状细胞癌易感性的关系
- Author:
Juan TAN
;
Zhenhua WANG
;
Chenyang YU
;
Haoyan CHEN
;
Jian GUAN
;
Yingxuan CHEN
;
Jingyuan FANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Esophageal neoplasms;
Carcinoma,squamous cell;
Variation (genetics);
GWAS;
Single nucleotide polymorphisms;
Toll-like receptor pathway
- From:
Chinese Journal of Digestion
2015;35(3):169-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between genetic variants in the Toll-like receptor (TLR) pathway genes and susceptibility of gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC).Methods The data of whole genome association studies of the high-risk population of GC and ESCC in China were analyzed by adaptive rank-truncated product (ARTP) method in pathway and gene level.The associations between single nucleotide polymorphism (SNP) and susceptibility of GC and ESCC were analyzed with additive model of unconditional Logistic regressions.PLINK 1.07 and SPSS 19.0 software were performed for statistical analyses,and ARTP package in R3.0.2 was used for pathway and gene level analysis.Results In gene-level analyses,eight genes were found to be associated with susceptibility of GC (P ＜0.05) and six genes were associated with susceptibility of ESCC (P ＜ 0.05).In single SNP-level analyses,21 SNPs were statistically correlated with susceptibility of GC (P ＜ 0.01),and 11 SNPs were statistically correlated with susceptibility of ESCC (P ＜0.01).Conclusions Some genetic variants in TLR pathway are associated with risk of GC and ESCC.The potential molecular mechanisms need further investigation.
