Stromal cell-derived factor 1 decreases β-amyloid deposition in Alzheimer's disease mouse model

VernacularTitle:基质细胞衍生因子1对阿尔茨海默病小鼠脑内Aβ的清除作用
Author: Qi WANG ; Wei WANG ; Dengji PAN ; Zhou ZHU ; Daiqi CHEN
Publication Type:Journal Article
Keywords: Alzheimer's disease; Beta amyloid; Microglia; Stromal cell derived factor-1; Chemo-taxis
From: Chinese Journal of Physical Medicine and Rehabilitation 2014;36(9):671-675
CountryChina
Language:Chinese
Abstract: Objective To explore whether stromal cell-derived factor 1 (SDF-1) can promote the clearance of β-amyloid deposition in the brain of APP/PS1 mice and the possible underlying mechanism.Methods Twelve 28-week-old APP/PS1 mice were divided into two groups:a treatment group and a control group.Animals were given the intracerebroventricular injection weekly with PBS or mouse recombinant SDF-1 α for eight weeks.Microglia and Aβ in cerebral cortex and hippocampal region of APP/PS1 mice were detected by immunofluorescence.Results After 8-week treatment,both the relative number and the relative area of Aβ deposits in the mice of treatment group were less than those in the control group.The relative number of plaque associated microglia increased to a significantly greater extent in the cortex and hippocampus in treatment group than those in the control group.Conclusion Injecting SDF-1α significantly reduced amyloid burden in APP/PS1 mice.This effect might associated with the improvement of the chemotoxis of microglia,which promote the phagocytosis of Aβ by microglia.