Clinical manifestations in eight patients with multiple dilated Virchow-Robin spaces in striatum
10.3760/cma.j.issn.1006-7876.2015.02.007
- VernacularTitle:基底节区大量扩大血管周围间隙患者八例临床特征分析
- Author:
Lixia ZONG
;
Yicheng ZHU
;
Jing YUAN
;
Jun NI
;
Lixin ZHOU
;
Liying CUI
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel diseases;
Basal ganglia cerebrovascular disease;
Cognition disorders;
Gait apraxia
- From:
Chinese Journal of Neurology
2015;48(2):103-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical feactures of patients with numerous dilated Virchow-Robin space in basal gangalia.Methods Eight patients with cribriform state in striatum in brain MRI at Peking Union Medical College Hospital from March 2013 to October 2013 were enrolled.The clinical data including age,gender,common vascular risk factors and clinical manifestations were analyzed.Cognitive functions,balance and gait disturbance,as well as activity of daily living were assessed.Results All of the eight patients are male,aged from 69 to 80.All the patients had a history of hyperlipidemia,while 7 of them had hypertension.The primary complaint was either gradual motor function decline or memory impairments (3/8),or dizziness (1/8).The other 4 of them were diagnosed as stroke or transient ischemic attack.Among the 8 patients,four had mild deterioration in activity of daily living function (Barthel index 65-85).Cognitive impairment was common (8/8,the Montreal Cognitive Assessment scores 19-27),while word recall was the mostly affected cognitive domain (8/8).Gait and balance dysfunction were found in three patients (3/8,Tinetti scores ≤ 24).Conclusions Man is more likely to have predisposition to cribriform state in striatum.Mild cognitive impairments and gait abnormality are common clinical manifestations of the disease.
