Expressions of miRNA141 and miRNA375 in serum samples from prostate cancer
10.3760/cma.j.issn.1671-7368.2015.03.019
- VernacularTitle:血清miRNA141和miRNA375在前列腺癌诊断中的意义
- Author:
Qipeng XIE
;
Jian YU
;
Xiaoqing CHEN
;
Huaikai WEN
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Laboratory techniques and procedures
- From:
Chinese Journal of General Practitioners
2015;14(3):228-230
- CountryChina
- Language:Chinese
-
Abstract:
To explore the diagnostic values of miRNA141 and miRNA375 for prostate cancer.The expressions of miRNA141 and miRNA375 in serum samples from 30 prostate cancer (PCA) patients,40 benign prostatic hyperplasia patients and 50 normal controls were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).The expression of miRNA141 in tissue samples from prostate cancer was 13.4±7.2 folds of that from benign prostatic hyperplasia while the expression of miRNA375 in tissue samples from prostate cancer was 28.4 ± 10.3 folds of that from benign prostatic hyperplasia.The differential expression of miRNA141 and miRNA375 in sera of prostate cancer suggested that miRNA141 and miRNA375 might be potential tumor markers in clinical practice.
