Comparative analyses of advanced gastric cancer on different chemotherapeutic protocols

VernacularTitle:不同化疗方案对晚期胃癌患者的疗效对比分析
Author: Lei FAN ; Huili ZHANG
Publication Type:Journal Article
Keywords: Stomach neoplasms; Antineoplastic combined chemotherapy protocols
From: Chinese Journal of General Practitioners 2015;14(6):450-452
CountryChina
Language:Chinese
Abstract: Objective A total of 86 cases with advanced gastric cancer were randomly divided into XELOX(capecitabine plus oxaliplatin) and FOLFOX4 (5-fluorouracil,leucovorin,and oxaliplatin)groups (n =43 each).The immediate efficacies were evaluated by the criteria of Response Evaluation Criteria In Solid Tumors (RECIST).Adverse reactions were compared between two groups.The overall effective rate were 56％ and 51％ in XELOX and FOLFOX4 groups.And there was no significant inter-group difference (P ＞ 0.05).The incidences of myelosuppression and nausea,vomiting in XELOX group were lower than those in FOLFOX4 group (P ＜ 0.05).And other adverse reactions had no inter-group statistical difference (P ＞ 0.05).Both chemotherapies were comparable in immediate efficacies for advanced gastric cancer.However,XELOX chemotherapy had a lower incidence of adverse reactions and it is more tolerable and compliant for patients.