Meta-analysis of donor human milk versus formula milk for feeding very low birth weight and extremely low birth weight infants
10.3760/cma.j.issn.1007-9408.2014.11.007
- VernacularTitle:捐赠母乳与配方奶喂养对极低和超低出生体重儿影响的meta分析
- Author:
Zhangbin YU
;
Shuping HAN
;
Xiaohui CHEN
;
Juan ZHOU
;
Beibei LIU
;
Li SHA
;
Xiaoyue DONG
- Publication Type:Journal Article
- Keywords:
Infant,low birth weight;
Breast feeding;
Infant formula;
Meta-analysis
- From:
Chinese Journal of Perinatal Medicine
2014;17(11):748-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of feeding donor human milk versus formula milk on very low birth weight infants (VLBWI) and extremely low birth weight infants (ELBWI).Methods The Cochrane library,PubMed,EMBASE,Wanfang,CNKI and VIP database were searched for the randomized controlled trials (RCT) that compare donor human milk with formula milk in VLBWI and ELBWI from the establishment of database up to February 2014.The quality of the included studies was assessed.Meta analysis was performed using RevMan 5.2.9 software.The results were expressed by mean difference (MD) and 95％CI for continuous variables,RR and 95％CI for categorical variables.Results Only five trials were included:in quality evaluation,two trials were graded B,and the other three were graded C.Meta-analysis showed that,compared with the formula milk,feeding of donor human milk could reduce the risk ofnecrotizing enterocolitis (RR=0.36,95％CI:0.18-0.73,P＜0.01),but not the risks of sepsis (RR=0.92,95％CI:0.50 1.72,P=0.80),retinopathy of prematurity (RR=1.21,95％CI:0.84-1.74,P=0.31) and in-hospital mortality (RR=0.66,95％CI:0.18-2.37,P=0.52).The significantly lower rates in weight gains in neonatal period (MD=-6.58,95％CI:-11.19 to-1.98,P＜0.01) and body length (MD=-0.30,95％CI:-0.41 to-0.20,P＜0.01)were found in donor human milk compared with formula milk.No significant difference in head circumference (MD=-0.16,95％CI:-0.33 to 0.01,P=0.13) was seen in comparison of donor human milk with formula milk.Conclusions Feeding with donor human milk can reduce the risk ofnecrotizing enterocolitis in VLBWI and ELBWI,but its effects on neonatal growth need to be further studied in large scale RCT.
