Reduction of hemoglobin induced by linezolid therapy: a retrospective study
10.3760/cma.j.issn.1671-7368.2014.12.015
- VernacularTitle:利奈唑胺致血红蛋白减少的回顾性研究
- Author:
Xiaohong MAO
;
Erzhen CHEN
;
Jie FANG
- Publication Type:Journal Article
- Keywords:
Linezolid;
Reduction of hemoglobin
- From:
Chinese Journal of General Practitioners
2014;13(12):1003-1005
- CountryChina
- Language:Chinese
-
Abstract:
The medical records of 197 patients on linezolid therapy were collected retrospectively.The prevalence and risk factors for linezolid-induced reduction of hemoglobin were identified.The incidence of linezolid-induced reduction of hemoglobin was 31.98％.The patients with reduction of hemoglobin had older age [(68 ± 14) vs.(59 ± 18) years,P =0.000] and lower creatinine clearance (CCr) [(72 ±42)vs.(98 ± 52) ml/min,P =0.000].Multivariate logistic regression analysis showed that age ≥65 years,treatment duration ≥ 15 days,CCr ＜ 65 ml/min and pre-treatment hemoglobin value ＜ 95 g/L were significant risk factors for linezolid-induced reduction of hemoglobin.
