Infections after pediatric living donor liver transplantation in 45 cases
10.3760/cma.j.issn.0254-1785.2015.03.007
- VernacularTitle:儿童亲属活体肝移植术后中重度感染分析
- Author:
Fengdong WU
;
Xinguo CHEN
;
Wei LI
;
Xiuyun REN
;
Bo YOU
;
Zhongyang SHEN
;
Zhijun ZHU
- Publication Type:Journal Article
- Keywords:
Infection;
Liver transplantation;
Living donors;
Child
- From:
Chinese Journal of Organ Transplantation
2015;36(3):161-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of infection and risk factors after pediatric living donor liver transplantation (PLDLT).Method Form April 2005 to April 2014 the clinical data of 45 cases of PLDLT in General Hospital of Chinese People's Armed Police Forces were retrospectively investigated,and the difference between the patients after PLDLT with infection and those without infection was analyzed.Result Eighty-four infections occurred in 27 (60.0％) of 45 patients,including 25 cases of bacterial infections,14 cases of viral infections,and 3 cases of candida albicans infections.Most infections occurring within 3 months after PLDLT have been found to be caused by bacteria,viruses and fungi.The trough level of tacrolimus (Tac) was in target therapeutic window in 16/20 infected patients and more than 10 ng/mL in 4/20 infected patients within 3 months after PLDLT,and there were 12/16 infected patients with the trough level of Tac of more than 10 ng/mL 3 months post-PLDLT,with the difference being significant (P＜0.05).Multivariate analysis revealed that post-transplant infection was significantly related with the factors as weight＜10 kg,age ＜12 months,biliary intestinal anastomosis,pediatric end-stage liver disease (PELD) score,ChildPugh score,total bilirubin,blood loss per kg body weight and graft to recipient weight ratio (GRWR).Logistic regression analysis suggested that PELD score was independent risk factor of infection after PLDLT.Conclusion The infection after PLDLT has their special characteristics.The proper irnmunosuppressive protocol and control of above risk factors are helpful to decrease the incidence of infection after PLDLT.
