The clinical features and treatment of autoimmune hemolytic anemia in patients after orthotopic liver transplantation
10.3760/cma.j.issn.0254-1785.2015.01.004
- VernacularTitle:肝移植术后自身免疫性溶血性贫血的临床特征与治疗
- Author:
Na LI
;
Lixin YU
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Autoimmune;
Hemolytic anemia
- From:
Chinese Journal of Organ Transplantation
2015;36(1):15-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical feature,pathogenesis and treatment of autoimmune hemolytic anemia (AIHA) in patients after orthotopic liver transplantation.Method A retrospective analysis was conducted on 7 patients who developed AHA after orthotopic liver transplantation.The clinical feature,pathogenesis and treatment of AIHA were reviewed.Result The incidence of AIHA was 0.98％ (7/713).AIHA occurred (7.9-± 4.0) (3-14) days after transplantation.All patients were characterized by progressive anemia and jaundice.Laboratory examination showed lower hemoglobin and platelet count,higher lactate dehydrogenase,higher indirect bilirubin and higher reticuloeyte count.The causes of AIHA included ABO-incompatible liver transplantation,infection and repeated transfusion.Conclusion AIHA is a rare and serious complication after liver transplantation.The most cause is ABO-incompatible liver transplantation.The patients can be successfully cured if the diagnosis is clarified and the treatment is definitive.
