The follow-up study of image guided 125I seed permanent brachytherapy for the treatment of unresectable pancreatic cancer
10.3760/cma.j.issn.1007-631X.2015.06.003
- VernacularTitle:影像引导下放射性粒子植入治疗不可切除胰腺癌的疗效评价
- Author:
Hongxin NIU
;
Xikun ZHANG
;
Zhongfa XU
;
Zhao ZHOU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Iodine isotopes;
Brachytherapy
- From:
Chinese Journal of General Surgery
2015;30(6):432-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of image-guided 125I radioactive seed interstitial implantation therapy for unresectable pancreatic cancer.Methods 25 patients with unresectable pancreatic cancer evaluated by retrospective follow-up were enrolled in this study,13 patients received radioactive seeds implantation while 12 patients were given non-surgical treatment.We observe and compare the clinical benefits,objective curative effect,complications,adverse reaction,survival between the two groups of patients.Results Compared with the non-surgical treatment group,the clinical benefit rate in the radiotherapy seed implantation group was 92％ (12/13) while that of the non-surgical group was 42％ (5/12),the difference was of statistically significance.The numbers of cases evaluated as effective were 6 (46％) and 4 (33 ％) respectively,the difference was not statistical significant (x2 =0.427,P ＞ 0.05);The radioactive seed implantation group had no serious postoperative complications;3 cases who received subsequent chemotherapy in radioactive seed implantation group(23％,3/13) and 3 cases in non-surgical treatment group(25％,3/12)suffered from serious adverse reactions,the difference was of no statistical significance(x2 =0.013,P ＞0.05);Comparing the survival rate between the two groups,x2 =0.001,P =0.969,the difference was of no statistical significance.Conclusions The therapy of 125I radioactive seed implantation for unresectable pancreatic cancer significantly relieves cancer caused pain and improves quality of life.
