A biocompatibility study on Allomax mesh implanted in different planes of abdominal wall in a rat model
10.3760/cma.j.issn.1007-631X.2015.05.016
- VernacularTitle:AlloMax补片植入大鼠腹壁不同层面后组织相容性研究
- Author:
Hailiang WANG
;
Hongjie SUN
;
Xiuqin WANG
;
Fengguo JIAN
- Publication Type:Journal Article
- Keywords:
Biocompatible materials;
Abdominal wall;
Histocompatibility
- From:
Chinese Journal of General Surgery
2015;30(5):391-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate biocompatibility of Allomax mesh implanted in different planes of abdominal wall in a rats model.Methods SD rats were randomly assigned to the profacial group (Onlay group),the retro-rectus group (Sublay group) versus the intraperitoneal group(IPOM group) according to different abdominal wall planes the mesh implanted,Adhesion and shrinkage of the mesh were observed,and quantitative measurements were conducted in fibroblast ingrowth,scaffold degradation,extracellular matrix deposition and numbers of vascular ingrowth after 1,3 and 6 months mesh was implanted.Results Macroscopic observation showed both Onlay and Sublay groups was superior to IPOM group in abdominal wall integration,which included shrinkage,relocation and adhesion of the mesh at all the time points,and most or whole of the mesh had incorporated with host abdominal wall at 6 months.Most of the mesh had not incorporated with host abdominal wall and shrinkage and relocation of the mesh were found in IPOM group at 6 months.Microscopic investigation showed lipocytes appeared in the mesh in Sublay group at 3 months,and numbers of ingrowth of fibroblast and neovascularization in Sublay group were significantly less than in Onlay and IPOM group at 6 months.Scaffold degradation and extracellular matrix deposition were remarkably less in Sublay group in comparison with Onlay group and IPOM group after 1,3 and 6 months.Conclusions Biocompatibility of AlloMax mesh implanted in profacial plane of abdominal wall was superior to implanted in retro-rectus plane and intraperitoneal plane as showed in a rat model.
