The clinical features and prognosis of 77 patients of breast cancer during pregnancy and lactation
10.3760/cma.j.issn.1007-631X.2015.04.013
- VernacularTitle:77例妊娠哺乳期乳腺癌的临床特点及预后分析
- Author:
Yan LIANG
;
Lina ZHANG
;
Yanfang YANG
;
Lin GU
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Breast neoplasms;
Mastectomy;
Therapy;
Prognosis
- From:
Chinese Journal of General Surgery
2015;30(4):300-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical features and prognostic factors of breast cancer during pregnancy and lactation.Methods A retrospective analysis was performed on 77 patients admitted to the Tianjin Cancer Hospital from January 2002 to December 2012.According to when the cancer was found,these patients were divided into the pregnancy group (n =23) and the lactation group (n =54).Survival rate was calculated by life table,Multivariate factors for survival were analyzed by COX proportional hazards regression model.Results The mean maximum diameter of the tumor was 5.9 cm,49 cases had axillary lymph node metastasis.Compared with the lactation group,the patients in pregnancy group had larger tumor diameter,the mean diameter was 6.8 cm (P =0.031).The median follow-up time was 39 months and 5-year disease-free survival (DFS) rate and 5-year overall survival (OS) rate were 52.6％ and 61.8％,respectively.Multivariate analysis showed that the independent factors of DFS and OS were breastfeeding and tumor size.Conclusions Diagnosis of breast cancer daring pregnancy and lactation were usually delayed and often in late TNM stage.Breastfeeding and tumor size are independent prognostic factors.
