Near-infrared fluorescence imaging with methylene blue for detecting sentinel lymph node in early breast cancer

VernacularTitle:荧光法联合染色法前哨淋巴结活检在早期乳腺癌中的应用
Author: Jun LIU ; Ning WANG ; Ping CHEN ; Linping HUANG
Publication Type:Journal Article
Keywords: Breast neoplasms; Sentinel lymph node biopsy; Methylene blue; Fluorescence imaging
From: Chinese Journal of General Surgery 2015;30(3):227-230
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical value of indocyanine green near-infrared fluorescence imaging with methylene blue for the sentinel lymph node biopsy (SLNB) in early breast cancer.Methods SLNB was performed in forty patients by fluorescence navigation with methylene blue.Frozen section was performed,followed by conventional histopathology.Results The identification rate of SLN was 100％.100％ of SLNs were fluorescent,with the average number being 2.88.92.5％ of SLNs were stained blue,with the average number being 1.75.The presence of lymph node metastasis was observed in intraoperative biopsy in 7 patients,and a total dissection of the axillary lymph nodes was performed immediately.Metastatic lesions were not found in the identified lymph nodes by intraoperative biopsy and permanent pathological diagnosis in the other 33 patients.Conclusions Sentinel lymph nodes biopsy by fluorescence navigation with methylene blue was a feasible minimally invasive technology with high detection rate.