Low microRNA-217 expression in colorectal cancer tissues predicts poor prognosis in colorectal cancer patients
10.3760/cma.j.issn.1007-631X.2015.02.014
- VernacularTitle:microRNA-217在结直肠癌中的表达及临床意义
- Author:
Bo WANG
;
Zhanlong SHEN
;
Yingjiang YE
;
Kewei JIANG
;
Shan WANG
;
Gang ZHAO
;
Chunyou WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
microRNA-217;
Prognosis
- From:
Chinese Journal of General Surgery
2015;30(2):134-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate microRNA-217 expression and its significance in colorectal cancer.Methods MiR-217 expression was detected in 30 cases of colorectal cancer tissues and corresponding adjacent normal colorectal tissues by qRT-PCR.The clinicopathologic correlations of miR-217 expression were performed using Fisher's exact test.Kaplan-Meier method was used to evaluate the overall survival of patients.Results MiR-217 was significantly lower in colorectal cancer tissues than in normal colorectal tissues (P ＜ 0.01).Moreover,the decreased miR-217 level was significantly associated with tumor size and TNM stage,as well as lymph node and distant metastasis.Meanwhile,patients of colorectal cancer with low levels of miR-217 expression had a significantly shorter median survival (x2 =4.584,P ＜ 0.05) than those with high levels of miR-217 expression.Conclusions Downregulated miR-217 in colorectal cancer tissues correlates to poor prognosis in postoperative colorectal cancer patients.
