Prognostic factors of papillary thyroid carcinoma in young people
10.3760/cma.j.issn.1007-631X.2015.02.009
- VernacularTitle:青少年甲状腺癌患者预后因素分析
- Author:
Weiye DENG
;
Yanfeng CHEN
;
Hao LI
;
Yunfei GAO
;
Zhuming GUO
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Carcinoma,papillary;
Adolescent;
Prognosis;
Recurrence
- From:
Chinese Journal of General Surgery
2015;30(2):115-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the treatment effect and factors affecting the prognosis in young people of papillary thyroid carcinoma (PTC).Methods A total of 69 PTC patients were reviewed retrospectively in Sun Yatsen University Cancer Center from Dec 1996 to Oct 2005.The prognostic status were compared using the Kaplan-Meier methods,the factors were analyzed by Log-rank test and the multiple factors were estimated by the Cox regression models.Results There were 26 males and 43 females.The median age was 24 years (mean:23.1 years).The average follow-up time was 113 months ranging from 73 to 174 months.20.3％ patients (14/69) experienced recurrence during follow-up time and 1.4％ patient (1/69) died.All the patients received levothyroxine after operation.The 10 year disease-free survival (DFS) rate of patients with or without extra thyroidal extension (ETE) of PTC was 29.6％ and 80.1％,respectively (P ＜ 0.01).Multivariate analysis showed that young PTC people with ETE had a worse prognosis (P =0.004).Conclusions Young papillary thyroid carcinoma patients had a favorable outcome.Surgical procedure was the first choice for this kind of patients.ETE was an independent factor for the recurrence of young PTC patients.
