The impact of donor age on early remnant liver function and regeneration after right lobe graft donation

VernacularTitle:供者年龄对成人活体右半肝移植术后残肝功能及再生的影响
Author: Qian JI ; Zhiqiang CHU ; Wen SHEN ; Hong ZHENG ; Ji QI
Publication Type:Journal Article
Keywords: Liver transplantation; Living donors; Age factors; Liver regeneration
From: Chinese Journal of General Surgery 2014;29(11):821-823
CountryChina
Language:Chinese
Abstract: Objective To evaluate the impact of donor age on early remnant liver function and regeneration after right lobe adult living donor liver transplantation (LDLT) donation.Methods 43 living donors were divided into 2 groups:donor age ＞ 50,n =8,and donor age ＜ 30,n =35.Alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TB) and liver regenerative ratio (LRR) of donors between the 2 groups were compared.Results There were no significantly different in ALT,AST and TB on days 1,2,3,5 after LDLT between the 2 groups (respectively t =0.147,1.030,-0.903,0.013,0.043,1.362,0.817,0.003,1.121,0.241,1.061 and 0.943,all P＞0.05).There was significant difference between LRR on day 7 (t =-0.965,P =0.042),but the difference was not statistically significant in LRR when evaluated on day 15 after LDLT (t =0.585,P =0.385).Conclusions Remnant liver regeneration on the first week is reversely affected by donor's age after hepatectomy,while the influence of age decreases significantly after 2 weeks.